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In congenital hyperinsulinism (CHI), mutations have been found in 5 different genes, ABCC8, KCNJ11, GCK, GLUD1 and SCHAD. In approximately 50% of all cases, however, no genetic explanation can be found.A mature newborn girl presented macrosomic, birth weight 4378 g, and a blood glucose down to 1.3 mmol/l at day 1. Hyperinsulinism was documented. The child responded to diazoxide treatment, initially in combination with prednisolone, chlorothiazide and oct...

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ea0029oc19.2 | Cardiovascular Endocrinology | ICEECE2012

Increased arterial stiffness is independently associated with cerebral infarctions and white matter lesions in patients with type 2 diabetes despite good blood pressure and lipid control

Laugesen E. , Hoyem P. , Gron B. , Mikkelsen A. , Kim W. , Thrysoe S. , Erlandsen M. , Christiansen J. , Knudsen S. , Hansen K. , Hansen T. , Poulsen P.

Aim: Patients with type 2 diabetes (T2DM) have increased risk of cardiovascular disease (CVD) including stroke. The risk of CVD is traditionally assessed using office blood pressure (BP) and lipid profile. Increased arterial stiffness predicts cardiovascular events in the general population. We investigated if arterial stiffness was associated with cerebrovascular disease in patients with T2DM and sex- and age-matched controls indepentl y of classical risk factors.<p class...

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Endocrine Abstracts

A TCF1 mutation may cause transient congenital hyperinsulinism followed by MODY3

Increased arterial stiffness is independently associated with cerebral infarctions and white matter lesions in patients with type 2 diabetes despite good blood pressure and lipid control

BiosciAbstracts